Interaction between periodontitis and diabetes has been studied for decades. But from the early 21's, the World Health Organization officially call for vigilance on the effects of periodontal disease on cardiovascular and cerebrovascular disease increases the risk of stroke, respiratory disease and the risk of respiratory infections in hospitalized patients, pregnant women increases the risk of premature birth, lack of birth weight.

According to the National Institute on teeth and the loss of the United States, people with periodontal disease are more prone to heart disease. Periodontal and is also the leading cause of tooth loss in adults, especially the elderly. More ominously, periodontitis is one of the complications of diabetes.